In the rats, we compared with the onset time and convulsed number on the generalized tonic convulsion between the control group that was administrated only lidocaine and the experimental group that was premendicated with baclofen, specific GABAB
receptor agonist, prior to lidocaine injection.
@ES The results were as follows :
@EN 1. In the control groups, according to increasing lidocaine dose, it was shortened the onset time and increased the convulsed number on the generalized tonic clonic convulsion induced by intraperitoneal lidocaine.
2. In the experimental groups, according to increasing of baclofen dose, it was delayed the onset time and decreased the convulsed number on the generalized tonic clonic convulsion induced by intraperitoneal lidocaine.
These results support the facts that baclofen, specific GABAB receptor agonist, has an anticonvulsant effect on the generalized tonic clonic convulsion induced by local anesthetics.
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